Effects of intermittent negative pressure treatment on circulating vascular biomarkers in patients with intermittent claudication
نویسندگان
چکیده
منابع مشابه
Patients with Intermittent Claudication
Increased blood viscosity has been shown to be an important factor in reducing blood flow in a review and analysis of the history, clinical findings, and haemodynamic, rheological, radiological, and biochemical measurements in 126 patients with intermittent claudication. In some patients increased viscosity seemed to be the determining cause of claudication. A raised plasma fibrinogen was the m...
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Cilostazol is a new phosphodiesterase inhibitor with anti-platelet and vasodilatory properties. Cilostazol and pentoxifylline are the only two drugs that have been approved for the treatment of patients with intermittent claudication. However, the mechanisms by which exercise tolerance is improved remain unclear. Vascular endothelial growth factor (VEGF) is a potent endothelial mitogen that res...
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produced by endothelial cells, smooth muscle cells (SMCs), and macrophages, and they oxidize low-density lipoprotein (LDL) to form oxidized LDL, which is taken up by macrophages to form foam cells. These in turn secrete growth factors that induce SMC migration into the intima, followed by fibrous plaque formation. Subsequent rupture of fibrous plaques leads to thrombus formation and vessel occl...
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Intermittent claudication is a common manifestation of peripheral arterial disease, its symptoms have a gradual onset and the patient may not notice them initially, instead accepting them as part of the ageing process. The main concern with intermittent claudication is the increased risk of cardiovascular or cerebrovascular events. This article highlights the relationship between these diseases...
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ژورنال
عنوان ژورنال: Vascular Medicine
سال: 2021
ISSN: 1358-863X,1477-0377
DOI: 10.1177/1358863x211007933